摘要
目的:探讨"相畏"中药肉桂与赤石脂配伍使用后对机体组织前列环素(PGI2)表达的影响。方法:将12只ICR/B F1小鼠随机分为空白组、肉桂组、赤石脂组、肉桂加赤石脂组。药物干预3 d后取机体各组织,以免疫组织化学方法检测各组不同组织中PGI2表达的差异性。结果:在脊神经、小肠上段、脾和胸腺中,肉桂组PGI2表达明显上调,肉桂加赤石脂组PGI2表达明显抑制。结论:在PGI2指标上,赤石脂可抑制肉桂的上调作用,表现为"相恶"。
Objective：To explore the effects of compatibility of cinnamon and halloysite on expression of prostacyclin（PGI_2）.Methods：Twelve ICR/B F1 mice were randomly divided into normal control group,cinnamon group,halloysite group,compatibility of cinnamon and halloysite group.Three days after drug administration,the PGI_2 expressions in different tissues were detected by immunohistochemical methods.Results：In the spinal nerve,upper intestine,spleen and thymus,the expressions of PGI_2 were increased in cinnamon group,while the expressions of PGI_2 were inhibited in compatibility of cinnamon and halloysite group.Conclusion：In the aspect of PGI_2 expression,halloysite can inhibit the up-regulation of cinnamon,and they shows ＂mutual inhibition＂ in compatibility.
出处
《上海中医药大学学报》
CAS
2011年第5期57-60,共4页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(30271615)
国家"十一五"科技支撑计划资助项目(2006BAI08B05-06)
关键词
肉桂
赤石脂
十九畏
前列环素
Cinnamon
halloysite
nineteen herbs of mutual restraint
prostacyclin
