骨肽注射剂致不良反应40例临床分析

Clinical analysis of 40 cases of adverse reactions caused by Ossotide for Injection

目的：探讨骨肽注射剂的不良反应发生特点。方法：检索《中国期刊全文数据库》（CNKI）1994～2010年骨肽注射剂不良反应文献进行统计分析。结果：骨肽注射刹不良反应以过敏反应最为常见21例（52．5％），其中过敏性休克10例（25．0％）。关节疼痛6例（15．0％），单纯药物热2例（5．0％），血尿2例（5．0％），高血钙1例。结论：根据骨肽注射液出现不良反应的可能原因，加强用药监护。

Objective：To study the characteristics of the adverse drug reactions （ADRs） induced by Ossotide for Injeetion.Methods： ADRs induced by Ossotide for Injection reported in domestic medical literatures during 1994-2010 were retrieved by means of CNKI,and the related database was established for statistic analysis.Results：In ADRs induced by Ossotide Injeetion,allergie reactions （21 eases, 52.5%） were more often seen, 10 eases （25.0%） were anaphylactic shock,6 cases（15.0%） were arthralgia,2 cases （5.0%） were drug fevers, 2 eases （5.0%）were hematuria and 1 case was hypcrcaleemia.Conclusion：Aeeording to the possible causes of ADRs, the medication monitoring should be strengthened.