雷公藤多苷联合青藤碱治疗类风湿关节炎49例

Treatment of 49 cases of rheumatoid arthritis by tripterygium glycoside and sinomenine

目的观察雷公藤多苷联合青藤碱治疗类风湿关节炎(RA)的临床疗效。方法将97例RA患者随机分为对照组(48例)和治疗组(49例);对照组口服雷公藤多苷片和甲氨蝶呤治疗,治疗组口服雷公藤多苷片和青藤碱治疗,疗程均为3个月。结果治疗组总有效率为100.0%,对照组为83.33%(P<0.05);治疗后,治疗组血沉(ESR)、类风湿因子(RF)和C反应蛋白(CRP)均明显降低(P<0.01),对照组ESR和RF有明显降低(P<0.05);且治疗组ESR、RF、CRP指标均低于对照组(P<0.05,P<0.01)。结论雷公藤多苷联合青藤碱治疗类风湿关节炎临床疗效确切。

Objective To observe the clinical efficacy of combined tripterygium glycoside and sinomenine in the treatment of rheumatoid arthritis（RA）.Methods Ninety-seven subjects were randomized into two groups： control group in which 48 cases were treated by tripterygium glycoside and methotrexate,and treatment group in which 49 cases were treated by tripterygium glycoside and sinomenine,with a course of three months.Results The overall effective rate was 100% in the treatment group and 83.33% in the control group（P0.05）;after treatment,the levels of ESR,RF and CRP were evidently reduced in the treatment group（P0.01）,and the levels of ESR and RF were evidently reduced in the control group（P0.01）;there were significant differences in the levels of ESR,RF and CRP between the two groups after treatment（P0.05,P0.01）.Conclusion Combined tripterygium glycoside and sinomenine is effective against rheumatoid arthritis.