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α-氨基酸-N-羧基内酸酐(NCAs)合成工艺研究进展 被引量：3

Recent Progress in the Synthesis of α-Amino acid N-carboxyanhydrides(NCAs)
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摘要 α-氨基酸-N-羧基内酸酐类化合物(NCAs)是一类重要的有机合成中间体,它被广泛用于多肽的合成。本文从不同的环合试剂出发概述了α-氨基酸-N-羧基内酸酐(NCAs)的合成方法。 The important chemical intermediates α-amlno acid N-carboxyanhydrides（NCAs）are widely used in the synthesis of polypeptides. This artical introduced some methods of using different cyclization reagents for formation of the α-amino acid N -carboxyanhydrides（NCAs）.
作者 张华 濮发祥 翁意意
机构地区 浙江工业大学药学院 浙江英特药业有限责任公司 浙江利民化工有限公司
出处 《浙江化工》 CAS 2011年第9期8-10,共3页 Zhejiang Chemical Industry
关键词 α-氨基酸-N-羧基内酸酐(NCAs) 中间体 多肽 α--amino acid N-carboxyanhydrides（NCAs） chemical intermediates polypeptides
分类号 TQ225.23 [化学工程—有机化工]
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参考文献11

  • 1Leuchs H. On the glycine carbonic acid. [machine translation] [J]. Chem. Ber., 1906, 39: 857-861.
  • 2Kricheldorf H R. a-Amino acid N-carboxy anhydrides and related heterocycles: syntheses, properties, peptide synthesis, polymerization. Springer-Verlag: Berlin, Heidelberg, 1987: 3-157.
  • 3Kricheldorf H R. Polypeptides and 100 years of chemistry of a-amino acid N-carboxyanhydrides [J]. Angew. Chem. Int.Ed., 2006, 45: 5752-5784.
  • 4Ben-Ishai D, Tchalski E. Synthesis of N-carboxy-α- amino acid anhydrides from N-(alkoxycarbonyl)-α-amino acids by the use of phosphorus tribromide [J]. J. Am. Chem. Soc., 1952, 74: 3688-3689.
  • 5Vayaboury W, Giani O, Collet H, et al. Synthesis of N t?-protected-L-lysine and C-benzyl-L-glutamate N- carboxyanhydrides (NCA) by carbamoylation and nitrosation [J]. Amino Acids, 2004, 27: 161-167.
  • 6Collet H, Bled C, Mion L, et al. A new simple and quantitative synthesis of α-amino acid-N-carboxyanhydrides (oxazolidines-2,5-dione) [J]. Tetrahedron Lett., 1996, 37: 9043- 9046.
  • 7Merslavic M, Crinski J. Process for preparing enalapril and enalaprilate: US, 5359086 [P]. 1994-10-25.
  • 8Ager D J, Babler S, Erickson R A, et al. The synthesis of the high-potency sweetener, NC-00637 Part 3: the glutamyl moiety and coupling reactions [J]. Org. Process Res. Dev., 2004, 8: 72-85.
  • 9Su W K , Weng Y Y, Zheng C, et al. Recent developments in the use of bis-(Trichloromethyl) -carbonate in synthesis [J]. Org. Process Res. Dev., 2009, 41: 93-141.
  • 10Su W K, Weng Y Y, Jiang L, et al. Recent Progress in the Use of Vilsmeier-Type Reagents [J]. Org. Process Res. Dev., 2010, 42: 503-555.

同被引文献39

  • 1杨坤,栾波,马楠,刘可,刘军,刘娜,顾斌,张维.阳离子型聚氨基酸的抑菌性能与生物安全性能的研究[J].中华老年口腔医学杂志,2020(3):140-145. 被引量：2
  • 2李芳,丛津生,赵博,赵新强,王延吉.非光气法合成1,5-萘二氨基甲酸甲酯的研究[J].石油学报（石油加工）,2005,21(5):48-53. 被引量：2
  • 3姚凯,王庭慰.L-谷氨酸苄酯-NCA与L-丙氨酸-NCA共聚物的合成研究[J].合成纤维工业,2006,29(1):24-27. 被引量：2
  • 4王卫国,杨明,李佩华,沈树宝.多肽合成中氨基酸活化酯的制备研究[J].化学试剂,2007,29(7):391-393. 被引量：3
  • 5Mhidia R, Boll E, Fcourt F, et al. Exploration of an imide capture/N, N- acyl shift sequence for asparaglne native peptide bond formation [ J ]. Bioorganic & medicinal chemistry, 2013, 21 (12) : 3479 - 3485.
  • 6Lenman M M, Lewis A, Gani D. Synthesis of fused 1,2,5 -triazepine - 1, 5 - diones and some N2 - and N3 - substituted derivatives: potential conformational mimetics for cis - peptidyl prolinamidesl [ J ]. Journal of the Chemical Society, Perkin Transactions 1, 1997 (16) : 2297 -2312.
  • 7Jung S, Tsukuda Y, Kawashima R, et al. Convenient synthesis of acetaminophen analogues containing ot - amino acids and fatty acids via their mixed carbonic carboxylic anhydrides in aqueous organic solvent [J]. Tetrahedron Letters, 2013, 54(42): 5718-5720.
  • 8Michel Brnnel J, Salmi C, Letourneux Y. Efficient peptide coupling method of conjugated carboxylic acids with methyl ester amino acids hydrochloride. Application to the synthesis of Fa - Met, an important enzymatic substrate[ J]. Tetrahedron letters, 2005,46 (2) : 217 -220.
  • 9Hpeg - Jensen T, Jakobsen M H, Holm A. A new method for rapid solution synthesis of shorter peptides by use of PyBOP [ J ]. Tetrahedren Letters, 1991,32 (44) : 6387 - 6390.
  • 10Coste J, Frret E, Jouin P, et al. Oxybenzotriazole free peptide coupling reagents for N - methylated amino acids [ J ]. Tetrahedron letters,1991,32 ( 17 ) : 1967 - 1970.

引证文献3

二级引证文献5

浙江化工
2011年 第9期

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