新透析器两种预冲方法对预防首用综合征的效果分析

Comparative analysis of two different pre-hedging methods for preventing the first-use syndrome in dialysis patients

目的比较新透析器两种预冲方法对预防首用综合征(first-use syndrome,FUS)的作用。方法将发生过FUS的60例患者随机分为治疗组和对照组各30例。治疗组患者新透析器采用上一次透析后残留在血路管静脉段的淡血水进行预冲及消毒灭菌处理后使用,对照组新透析器采用0.9%生理盐水常规预冲后使用。比较新透析器两种预冲方法患者透析过程FUS发生情况。结果治疗组患者无发生FUS,对照组发生率为20.0%,两组比较,差异具有统计学意义(P<0.05)。结论新透析器使用自身残留淡血水灌新透析器进行预冲,可降低患者发生FUS。

Objective To compare the two different pre-hedging methods for preventing the first-use syndrome in dialysis patients. Methods 60 patients contracting first-use syndrome were randomly divided into the treatment group and the control group. In the treatment group,the blood and water left in the dialyzers were poured into a new dialyzer,soaked for 30 min,drained,washed,and held for 24 hours. In the control group,the new dialyzers were filled with 500 mL saline,emptied fully and then flushed with 500 mL saline,and finally were closed with 20 mg heparin for 20 min. Results No first-use syndromes were observed in treatment group and 20.0% in control group. There were significant differences statistically in the two groups（P 0.05） . Conclusion The disinfection of the new dialyzers by way of soaking may reduce the incidence of first-use syndrome.