超高效液相色谱-串联质谱法测定食品包装材料中全氟辛烷磺酸盐

Determination of Perfluorooctane Sulfonates (PFOS) in Food Packaging Materials by UPLC/MS/MS

建立了超高效液相色谱-串联质谱(UPLC-MS/MS)测定食品包装材料中全氟辛烷磺酸盐(PFOS)的方法.采用乙腈作为溶剂,加速溶剂提取法提取食品包装材料中的PFOS.色谱条件:ACQUITY UPLC BEH C18色谱柱(1.7μm,2.1 mm×50 mm);柱温:30℃;流动相:乙腈/水,梯度洗脱;流速:0.2 mL/min;经UPLC分离后用多级反应监测(MRM)方式测定.用2个子离子的相对丰度定性,外标法定量.PFOS在0.005～0.500μg/mL范围内线性良好(R2=0.999),PFOS的回收率为90.0%～101.6%,相对标准偏差RSD为1.5%～3.5%.方法检出限为0.1μg/m2(S/N≥3).

A novel method based on the ultrahigh performance liquid chromatography tandem mass spectrometry（UPLC/MS/MS） for the detection of perfluorooctane sulfonates（PFOS） in food packaging materials has been set up.The chromatographic conditions ware： the column used was ACQUITY UPLC BEH C18（1.7 μm,2.1 mm×50 mm）;the temperature of column was 30 ℃;the mobile phase was acetonitrile/water,with gradient elution;the flow rate was 0.2 mL/min.PFOS was detectable using the electrospray ionization（ESI） on a tandem mass spectrometer in a multiple reaction monitoring mode.Qualitative analysis of PFOS was performed using the relative abundance of two daughter ions of PFOS,and quantitative analysis was conducted with the external standard method.The linear calibration curve was obtained in the range of 0.005～0.500 μg/mL with a linear correlation coefficient（R2） of 0.999.The recoveries for PFOS were 90.0%～101.6% with relative standard deviations of 1.5%～3.5%.And the detection limit for PFOS was 0.1 μg/m2（S/N≥3）.