新生儿导管相关性真菌血流感染危险因素分析

Risk factors of central venous catheter related fungemia in newborns

目的分析新生儿病房发生导管相关性真菌血流感染的原因,探讨控制医院感染的有效手段。方法回顾性分析2008年12月-2009年1月新生儿科发生的医院感染病例,对其病原学特征、临床特点及感染因素等情况进行分析,得到相关结果并探讨预防策略。结果医院感染发生率为2.69%,均与中心静脉置管有关;病原菌以假丝酵母菌属为主;早产、基础疾病、免疫力低下、联合使用广谱抗菌药物、侵入性操作是引起感染高危因素。结论新生儿导管相关性真菌血流感染与菌群移位、接触传播、静脉输入等因素有关,针对各可能的环节采取综合的预防控制措施,可以减少医院感染的发生。

OBJECTIVE To discuss the risk factors of central venous catheter related fungemia in newborns and effectively control hospital infection.METHODS The cases of infections in Neonatal ward from Dec 2008 to Jan 2009 were retrospectively analyzed.The factors including pathogenic characteristics,clinical features,and so on were analyzed.RESULTS In two months,the hospital infection rate was 2.69%.All infected newborns had received central venous catheter.Candida was the main pathogens.The predisposing factors included premature,underlying diseases,being immunocompromised,joint using the broad-spectrum antibiotics and receiving invasive treatment.CONCLUSION The ssources of pathogens from catheter related bloodstream infection are related to bacterial translocation,contact transmission,Intravenous and other factors.comprehensive prevention and control measures for each possible link can reduce the incidence of hospital infection.