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综合医院耐甲氧西林金黄色葡萄球菌的临床分布及耐药性研究 被引量:8

Investigation of clinical features and resistance of methicillin-resistant Staphylococcus aureusin general hospital
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摘要 目的了解综合医院耐甲氧西林金黄色葡萄球菌(MRSA)感染流行现状及耐药性,为MRSA的医院感染控制及临床治疗提供依据。方法采用回顾性调查方法,对119例MRSA感染患者的临床资料和病原菌及耐药率进行统计分析。结果医院获得性耐甲氧西林金黄色葡萄球菌(HA-MRSA)与社区获得性耐甲氧西林金黄色葡萄球菌(CA-MRSA)均以下呼吸道感染为主,HA-MRSA占63.03%,两者在年龄、住院天数、侵入性操作、基础疾病等方面存在明显差异;HA-MRSA对克林霉素、红霉素、四环素等耐药性明显高于CA-MRSA。结论 CA-MRSA与HA-MRSA在临床分布及耐药性方面存在显著差异,应加强重点部门、高危人群监测,合理使用抗菌药物,采取有效的消毒隔离措施,减少MRSA医院感染的暴发、流行。 OBJECTIVE To investigate the epidemiological characteristics and resistance of Methicillin-resistant Staphylococcus aureus(MRSA) in General Hospital,in order to make reference for infection control and clinical medication.METHODS A retrospective investigation method was used to collect data of 119 MRSA cases,then analyzing the clinical data and drug sensitivity test.RESULTS The community-associated MRSA and hospital-acquired MRSA infections were mainly on the lower respiratory tract position.63.03% were Healthcare-associated MRSA.There was significont difference in age,the length of days,invasive operation and the basic diseases.HA-MRSA had significantly higher resistance rate than that of CA-MRSA in clindamycin,erythromycin,tetracycline,and so on.CONCLUSION CA-MRSA and HA-MRSA cases differ demographically and clinically.The key measures to prevent infection of hospital-associated MRSA are monitoring key departments and susceptible patient,taking effective disinfection,reducing invasive procedures,using antibiotics drugs rationally.
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2011年第20期4359-4361,共3页 Chinese Journal of Nosocomiology
关键词 综合医院 耐甲氧西林金黄色葡萄球菌 临床分布 耐药性 General hospital Methicillin-resistant Staphylococcus aureus Clinical distribution Bacterial resistance
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