摘要
目的分析外科感染患者细菌分布及耐药分析,为临床合理应用抗菌药物治疗细菌感染提供依据。方法将2009年1-12月医院外科感染送检的标本按照《全国临床检验操作规程》进行检测。结果细菌分布前3位为大肠埃希菌、铜绿假单胞菌和凝固酶阴性葡萄球菌,分别占22.4%、11.4%和11.3%;产ESBLs大肠埃希菌检出率达52.9%,呈现多药耐药性,对亚胺培南、哌拉西林/他唑巴坦耐药率较低,分别为0、2.6%;革兰阳性菌中86.5%的凝固酶阴性葡萄球菌是MRCNS,61.2%的金黄色葡萄球菌是MRSA,它们对万古霉素、利奈唑胺、替考拉宁的耐药率为0。结论根据对外科感染患者细菌构成分布和药敏结果的把握,进行经验性治疗,一旦获得药敏结果,及时选用敏感药物,对提高治疗效果有重要意义。
OBJECTIVE To study the bacteria distribution and drug resistance of surgical infection to provide evidences for rational use of antibiotics in treatment of bacterial infection.METHODS All samples of surgical infection in our hospital in 2009 were detected according to National Operating Procedure of Clinical Analysis.RESULTS E.coli was the most frequent pathogen of G-infection with high percentage of ESBLs isolates which showed multi-drug-resistance to antibiotics except for imipenem and piperacillin/tazobactam.MRCNS and MRSA constituted a certain percentage of G＋ infection.No drug-resistance to vancomycin,linezolid or teicoplanin was detected.CONCLUSIONS Choosing antibiotics according to the records of bacteria distribution and drug-resistance and switching to sensitive drug once after we get the pathogen isolation result,this is very important to improve the therapeutic effect of surgical bacterial infection.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第20期4388-4390,共3页
Chinese Journal of Nosocomiology
关键词
病原菌
抗菌药物
耐药性
外科感染
Pathogen
Antibiotics
Drug resistance
Surgical Infection
