124例口腔真菌感染患者临床特征分析

Clinical features of 124 cases with oral fungus infections

目的探讨口腔真菌感染患者临床特征。方法回顾性分析124例口腔真菌感染患者的临床资料。结果口腔真菌感染患者以义齿修复、儿童及老年人、口腔卫生差者为主,分别占30.6%、20.2%、17.7%;分离出假丝酵母菌属120株,占96.8%,以白色假丝酵母菌为主,占82.3%;假丝酵母菌属对伊曲康唑、氟康唑耐药率相对较高,为47.5%、25.8%,对5-氟胞嘧啶、制霉菌素和两性霉素B耐药率较低,分别为1.7%、0.8%、0。结论义齿修复、体质差的儿童及老年人和口腔卫生差是口腔真菌感染的易感因素,分离的真菌主要为白色假丝酵母菌,并且呈现出一定的耐药性,应加强监测。

OBJECTIVE To explore the clinical features of patients with oral fungus infection.METHODS The clinical data of 124 cases with oral fungus infection were reviewed.RESULTS Oral fungus infections occurred more often in children or the elderly（20.2%）,and the cases with denture repair（30.6%） and poor oral hygiene conditions（17.7%）.Candida（120 strains,96.8%） and Mold（4 strains,3.2%）,and Saccharomyces albicans（82.3%） was the very common fungus.Candida showed high drug-resistence to itraconazole（47.5%） and fluconazole（25.8%）,and low or no drug-resistance to 5-flucytosine（1.7%）,nystatin（0.8%）,and amphotericin B（0）.CONCLUSION Denture repair,children or the elderly with poor constitution,and poor oral hygiene conditions are the risk factors of oral fungus infections.Saccharomyces albicans is the very common fungus,and has a certain resistance.We should strengthen the monitoring.