葛根素聚维酮K30固体分散体的制备及体外评价

Preparation and in vitro Evaluation of Puerarin-Polyvinylpyrrolidone K30 Solid Dispersions

目的:制备葛根素-聚维酮(PVP)K30固体分散体以提高葛根素的溶出速率。方法:以PVP K30为载体,采用溶剂法制备葛根素-PVP固体分散体,并优选葛根素和PVP K30的最佳比例。通过溶出试验、差示扫描量热法、红外光谱、X射线衍射等方法对固体分散体的性质进行评价。结果:以最佳比例(葛根素-PVP K30 1∶3)制备的固体分散体中葛根素的溶出速率是原料药的2倍;差示扫描量热法、红外光谱及X射线衍射结果表明固体分散体中葛根素以无定形形式存在,并可能与PVPK30有氢键形成。结论:采用溶剂法制备葛根素-PVP固体分散体可显著提高葛根素的溶出速率。

Objective：To prepare solid dispersions of puerarin with polyvinylpyrrolidone K30（PVP K30） to improve dissolution of puerarin.Method：Solid dispersion of puerarin-PVP was prepared by solvent method with PVP K30 as carrier.And the best proportion of puerarin to PVP K30 has been optimized.Nature of the solid dispersion was evaluated by dissolution test,differential scanning calorimetry（DSC）,infrared spectroscopy（IR） and X-ray diffraction（XRD）.Result：Optimum proportion of puerarin to PVP K30 was 1∶3.Dissolution rate of puerarin in the solid dispersions was 2 folds as that of material medicine.The results of DSC,IR and XRD showed that puerarin in the solid dispersion was amorphous form,and hydrogen bond may have been formed between puerarin and PVP K30.Conclusion：Dissolution rate of puerarin could be improved in solid dispersion of puerarin-PVP which prepared by solvent method.