不同粒径炉甘石体外透皮渗透作用比较

Comparative on in vitro Transdermal Permeability of Calamine with Different Sizes

目的:比较不同粒径炉甘石洗剂对体外透皮渗透作用的影响。方法:采用改良Franz扩散池,以离体大鼠皮肤为渗透屏障,用滴定法测定氧化锌的渗透量,并计算透皮速率常数、滞后时间。结果:氧化锌的体外透皮渗透符合零级动力学方程,其中1000目粒径炉甘石体外渗透效果相对较好。结论:随着炉甘石粒径的减小,氧化锌的累计渗透量有增高趋势,有利于透皮渗透。

Objective： To compare transdermal permeability properties in vitro of Calamine lotion with different mesh size.Method： Modified Franz diffusion cell was used,excised rat skin was applied as permeability barriers.Permeability quality of ZnO was determined by titration,transdermal rate constant and lag time were computed.Result： Transdermal permeability in vitro of ZnO in vitro was in accordance with zero-order release kinetics.Compared with other size,transdermal permeability in vitro of Calamine with 1 000 mesh size was relatively good.Conclusion： With size of Calamine decreasing,accumulative penetration amount trended to increase,and contributed to transdermal permeability.