地锦草滴丸的制备工艺

Preparation Technology of Euphorbiae Humifusae Herba Dropping Pills

目的:优选地锦草滴丸的制备工艺。方法:以外观质量为评价指标,采用正交设计试验对各影响因素进行考察,从药物与基质配比、冷凝柱长、滴头内径等方面进行选择。结果:滴丸成型最佳工艺为PEG4000-PEG6000(1∶7)为基质,药物与基质的质量比1∶3,药液熔融温度(82±2)℃,冷凝液甲基硅油,冷凝柱长15 cm,冷凝温度(1～3)℃,滴头内径3.0 mm,滴速30 d.min-1。结论:选取的处方及滴制工艺合理、简便。所制滴丸外观质量好,丸重差异小。

Objective：To optimized the preparation technology of Euphorbia Humifusa Herba dropping pills.Method：Used appearance quality as evaluation criteria,investigated factors by using orthogonal design.The factors included ratio of drug to matrix,length of condensation pole,inside diameter of burette and so on.Result：Optimum technology of dropping pills was as follows： matrix was a mixture of polyethylene glycol 4000 and polyethylene glycol 6000（1∶7）,ratio of drug to matrix was 1∶3 at temperature of（82±2） ℃,condensate was dimethicone at（1-3） ℃,length of condensation pole was 15 cm,inside diameter of burette was 3.0 mm,dropping speed was 30 drops per minute.Conclusion：The prescription and preparation technology were reasonable and simple,Under above preparation process,appearance quality of dropping pills was fine,and subtle difference among pill weights.