序贯法观察肉桂对马钱子的减毒作用

Effect of Cinnamon on Strychnos Studied by Sequential Acute Toxicity Test

目的:研究肉桂对马钱子的减毒作用。方法:单纯马钱子煎液、马钱子肉桂煎液(马桂煎液1∶5),其中马钱子生药含量都是20%。用序贯试验测定两种马钱子制剂的LD50。比较其毒性。结果:单纯马钱子LD50=(173.161±18.289)mg.kg-1,马桂煎液LD50=(781.345±214.744)mg.kg-1,马桂煎液从中毒至死亡时间明显延长。结论:马钱子与肉桂合煎后毒性明显降低。

Objective： To study the attenuated effect of cinnamon on strychnos.Method： The mice were administrated with strychnos decoction or strychnos-cinnamon decoction（strychnos∶cinnamon=1∶5） intragastrically.The half lethal dose（LD50） of both decoctions were studieded and compared by the sequential acute toxicity test.Result： LD50 of the two decoction were strychnos decoction=（173.161±18.289） mg·kg-1,strychnos-cinnamon decoction=（781.345 ± 214.744） mg·kg-1.In addition,the average time from poisoning to death of the mice administrated with strychnos-cinnamon decoction was significantly longer than that of mice with strychnos deconction.Conclusion： Cinnamon can reduce the toxicity of strychnos significantly.