环氧化酶-2和基质金属蛋白酶-7在胃癌组织中的表达及意义

Clinical significance of expression of COX-2 and MMP-7 protein in human gastric carcinoma

目的探讨环氧化酶-2(COX-2)及基质金属蛋白酶-7(MMP-7)在胃癌中的表达,关注二者的关系及临床意义。方法采用免疫组化Envision法检测117例胃癌术后存档的标本作为研究对象,以44例正常胃黏膜组织作为对照组,检测两组中COX-2和M M P-7的表达。结果胃癌组织中COX-2、M M P-7表达阳性率为59.0%(69/117)和60.7%(71/117),而正常胃组织中均呈低表达或不表达,两者差异有显著性(P<0.01);二者表达均与肿瘤浸润深度、临床分期及淋巴结转移呈明显正相关(P<0.05);相关性研究显示COX-2表达与M M P-7表达呈明显正相关。结论胃癌组织中COX-2、MMP-7异常表达,可促进胃癌的浸润、转移,对判断胃癌预后有一定价值。

【Objective】 To investigate the expression of COX-2 and MMP-7 protein in gastric carcinoma and explore their relationship and clinical significance.【Methods】 The expression of COX-2 and MMP-7 was detected by Envision immunohistochemistry in 117 gastric cancer specimens collected after operations and 44 cases of normal gastric mucosa as control.【Results】 The expression rates of COX-2 and MMP-7 protein in gastric cancer tissues were 59.0% and 60.7%,lower expression or no positive expression in normal gastric mucosa tissue（P 0.01）.The positive rate of COX-2 and MMP-7 expression was related with tumor differentiation depth of invasion,TNM stage and lymphatic metastasis（P 0.05）.There was a significant positive correlation between COX-2 and MMP-7 expression in gastric cancer.【Conclusions】 The overexpression of COX-2 and MMP-7 in gastric carcinoma enhances the possibility of invasion and metastasis and could be one of the signs of the poor prognosis.