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人类的线粒体疾病 被引量：1

Mitochondrial Disorders in Humans
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摘要 针对人类的线粒体疾病,阐述人类线粒体mtDNA的结构特点、线粒体疾病的定义及其遗传学特点;线粒体疾病的病因和发病几率以及常见的人类线粒体疾病;介绍了现已掌握的线粒体疾病的治疗方法,展望了线粒体疾病的未来研究方向。 The article summarized structural character of mtDNA, definition and genetics character of mitochondrial diseases, pathogeny and mechanism of mitochondrial diseases, familiar mitochondrial diseases, therapeutic methods of mitochondrial diseases in humans.
作者 孙洪兆 赵术珍
机构地区 齐鲁师范学院生物系 山东省农业科学院高新技术研究中心
出处 《齐鲁师范学院学报》 2011年第5期147-150,共4页 Journal of Qilu Normal University
基金 山东省高等学校科技计划项目(J11LC17)资助
关键词 线粒体 MTDNA 遗传学特点 疾病 Mitochondria mtDNA Genetics character Disease
分类号 Q244 [生物学—细胞生物学]
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参考文献9

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共引文献2

同被引文献28

  • 1Thorbum DR, Dah HH. Mitochondrial disorders: genetics, counseling, prenatal diagnosis and reproductive options. Am J Med Genet, 2001, 106(1):102-14.
  • 2Dinopoulos A, Cecil KM, Schapiro MB, et al. Brain MRI and proton MRS findings in infants and children with respira- tory chain defects. Neuropediatrics, 2005, 36(5):290-301.
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  • 7Kaufinann P, Engelstad K, Wei Y, et al. Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clini- cal trial. Neurology, 2006, 66(3):324-30.
  • 8Brown DT, Samuels DC, Michael EM, et al. Random geneticdrift determines the level of mutant mtDNA in human primary oocytes. Am J Hum Genet, 2001, 68(2):533-6.
  • 9Cohen 2, Scott R, Schimmel T, et al. Birth of infant after transfer of anucleate donor oocyte cytoplasm into recipient eggs. Lancet, 1997, 350(9027): 186-7.
  • 10Barritt JA, Brenner CA, Malter HE, et al. Mitochondria in human offspring derived from ooplasmic transplantation. Hum Reprod, 2001, 16(3):513-6.

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齐鲁师范学院学报
2011年 第5期

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