缬沙坦治疗慢性心力衰竭40例疗效观察

Clinical observation of valsartan in treatment of chronic heart failure of 40 Cases

目的观察缬沙坦治疗慢性心力衰竭的临床疗效。方法选择80例慢性充血性心力衰竭患者,心功能Ⅱ～Ⅳ级,随机分为治疗组和对照组各40例,对照组采用常规治疗方法,治疗组在常规治疗的基础上加用缬沙坦,治疗4个月,观察两组的临床疗效和心功能改变。结果治疗组治疗后LVEDD、LVESD、LVEF、左心室短轴缩短率(FS)及BNP较治疗前改善(P<0.05,P<0.01),对照组治疗后LVEDD、FS、LVEF较治疗前改善(P<0.05,P<0.01);两组治疗前比较,LVEDD、LVESD、FS、LVEF及BNP水平差异无统计学意义(P>0.05);两组治疗后比较,LVEDD、LVEF及BNP差异有统计学意义(P<0.05)。结论缬沙坦治疗慢性心力衰竭疗效好、不良反应少,患者耐受性佳,是慢性心力衰竭可靠的治疗药物。

Objective To observe the clinical efficacy of valsartan in chronic heart failure.Methods Totally 80 cases of patients with chronic congestive heart failure,cardiac function Ⅱ ～Ⅳ grade.Randomly divided into two groups,one group with conventional treatment,and the other group received valsartan,treatment for 4 months,clinical efficacy and cardiac function were observed.Results After treatment,the LVEDD,LVESD,LVEF,left ventricular fractional shortening（FS） and BNP before treatment improved（P〈0.05,P〈0.01）,the control group after treatment,LVEDD,FS,LVEF improved compared with before treatment（P〈0.05,P〈0.01）;Two groups before treatment,LVEDD,LVESD,FS,LVEF and BNP levels had no significant differences（P〉0.05）;Two groups after treatment,LVEDD,LVEF,and BNP difference Were statistically significant（P〈0.05）.Conclusions Valsartan is effective treatment of chronic heart failure,less side effects,good patient tolerance,is a reliable treatment of chronic heart failure.