高胰岛素血症：因还是果？

Hyperinsulinemia： cause or consequence

2011年美国糖尿病协会（ADA）年会Banting科学成就奖获得者为波士顿大学的Barbara E．Corkey。她提出2型糖尿病的先决原因是高胰岛素血症，而胰岛素抵抗是其后的代偿。基础胰岛素分泌过剩的原因在于环境因素。其提出2型糖尿病的发病模型是：环境因素造成了高基础胰岛素血症。而环境因素导致胰岛素分泌过剩的共同路径是氧化还原反应的紊乱。

The Banting Lecture of American Diabetes Association （ADA） annual meeting in 2011 was delivered by Barbara E. Corkey of Boston University. She believes that the root cause of type 2 diabetes is hyperinsulinemia, and then insulin resistance as compensation. The cause of excess insulin secretion is something in the environment. Her proposed model for type 2 diabetes is ： basal hyperinsulinemia caused by environmental background. Her investigations have caused her to hypothesize that the common path leading from these environmental agents to secretion of excess insulin is redox perturbations.