自噬与脂代谢

Relationship between autophagy and lipid metabolism

自噬是细胞清除受损或多余的蛋白质和细胞器的降解过程。最近研究发现，脂滴也是自噬过程的底物之一。在营养状态改变时，自噬能够根据机体需要增加或减少对脂滴的降解，从而起到调节脂代谢的作用。此外，自噬在脂滴形成及脂肪组织分化过程中也发挥重要作用。在细胞水平以自噬为靶点是治疗肥胖、胰岛素抵抗和2型糖尿病的新途径。

Autophagy is a celler degradation pathway in which damaged or superfluous proteins and organelles are cleared. Recently, lipid droplets （LDs） have been identified as a substrate for macroautophagy. The ability of autophagy to respond to changes in nutrient supply allows the cell to alter LD metabolism to meet the cell＇s energy demands. In addition,autophagy plays an important roles in the formation of LD and differentiation of lipid tissue. Autophagy therefore represents a new cellular target for abnormalities in lipid metabolism and accumulation.