摘要
目的探讨喹硫平治疗单相抑郁障碍的疗效及安全性。方法将符合入组标准的77例单相复发抑郁障碍患者随机分为喹硫平组(38例)和西酞普兰组(39例),疗程8周,以汉密尔顿抑郁量表(HAM D)和汉密尔顿焦虑量表(HAM A)评定临床疗效,以副反应量表(TESS)评定药物不良反应。结果治疗1周末喹硫平组HAM D、HAM A减分优于西酞普兰组(t=2.16,t=2.33;P均<0.05),8周末时两组间未见显著差异(t=0.71,t=1.49;P均>0.05);治疗结束时喹硫平组与西酞普兰组治愈率和有效率分别为34.2%,57.9%和35.9%,61.5%,差异无统计学意义(χ2=0.0241,0.1062;P均>0.05);喹硫平组头晕、口干、体重增加发生率显著多于西酞普兰组。结论喹硫平治疗单相抑郁障碍的疗效与西酞普兰相当,但头晕、口干、体重增加等不良反应较多见。
Objective To explore the effect and security of Quetiapine in the treatment of unipolar depression.Methords A total of 77 patiens of unipolar recurring depression patients were divided into Quetiapine group(38 cases)and Citalopram group(39 cases).The couse of treatment was 7 days.The clinical effects were evaluated by the scale of HAMD,HAMA,and the adverse reactions were assessed by the scale of TESS in the same time.Results After 1 wee k of treatment,the decreasing points of HAMD and HAMA in the Quetiapine group were better than the Citalopram group(t=2.16,2.33;P0.05),while there were no significant difference between the two groups at the end of the 8 weekend(t=0.71,1.49;P0.05).The cure and effective rate in the Quetiapine group and Citalopram group were 34.2%,57.9%,and 35.9%,61.5% at the end of the treatment,there were no statistic difference(χ2=0.0241,0.1062;P0.05).The symptoms of dizziness,dry mouth,weight gain in the Quetiapine group were much more than those of the group of Citalopram.Conclusion There are similar curative effects for the patiens of unipolar depressive disorder by the treatment of Quetiapine and Citalopram,but adverse reactions in the Quetiapine such as dizziness,dry mouth and weight gain are more common.
出处
《中国健康心理学杂志》
2011年第9期1031-1032,共2页
China Journal of Health Psychology