氟喹诺酮类药物临床常见不良反应研究

目的:了解氟喹诺酮类抗菌药物在临床治疗中发生不良反应的情况,探讨氟喹诺酮类药物导致的不良反应发生的临床特点和分布规律。方法:收集我院在2010年1月-12月期间发生的115例氟喹诺酮类药物所致不良反应的患者的临床资料,采用回顾性分析方法,对数据总结分析。结果:氟喹诺酮类药物不良反应男性发生率明显高于女性的发生率(P<0.05);38～58岁是氟喹诺酮类药物不良反应发生的主要年龄段,明显高于其他年龄段(P<0.05)。不良反应临床表现主要以神经系统为主;38-58岁年龄段不良反应发生时间和恢复时间均明显高于其他年龄段(P<0.05)。结论:临床应用氟喹诺酮类药物时要充分认识其不良反应发生情况,提高合理用药水平,注意预防可能发生的不良反应,降低不良反应的发生率。

Objective： To evaluate fluoroquinolone adverse resctions caused by the clinical characteristics and distribution. Methods： A retrospective analysis of 115 patients of our hospital from January 2010 1 - 12 months, they were treated adverse reactions of fluoroquinolones in patients with clinical data, and data were analyzed. Results ： Fluoroqulnolone adverse reactions were significantly higher than the male rate of females （ P 〈 0.05 ） ; 38 - 58 years of age is adverse reactions of fluoroquinolones main age groups, significantly higher than other age groups （ P 〈 0.05 ）. Clinical manifestations of adverse reactions based mainly on the nervous system; 38- 58 age group adverse reaction time and recovery time were significantly higher than other age groups （ P 〈 0.05）. Conclusions ： Fluoroquinolones should be fully understood adverse events, the clinician should improve clinical medication level and attention to the possible prevention of adverse reactions to reduce the incidence of adverse reactions.