摘要
目的:研究香青兰总黄酮在大鼠各肠段的吸收动力学特征。方法:采用大鼠在体肠灌流模型,利用HPLC法测定灌流液中田蓟苷的浓度,研究田蓟苷和香青兰总黄酮在大鼠各肠段的吸收特性。结果:香青兰总黄酮中田蓟苷在大鼠各肠段的吸收速率常数Ka值按结肠、空肠、十二指肠、回肠顺序依次分别为5.7651×10-2,4.4081×10-2,4.3873×10-2,3.9899×10-2;田蓟苷在大鼠各肠段的吸收速率常数Ka值按十二指肠、回肠、空肠、结肠顺序依次分别为6.7897×10-2,6.3018×10-2,5.8011×10-2,5.6765×10-2。结论:田蓟苷单体与香青兰总黄酮中田蓟苷在大鼠各肠段的吸收特征相一致,二者在大鼠小肠段不同部位的吸收均不存在差异。
OBJECTIVE To investigate the absorption characteristics and its mechanism of Dracocephalum total flavones in various intestinal segments. METHODS In situ single-pass intestinal perfusion model and HPLC were used to study the intestinal absorption of tilianin in the four intestinal segments. RESULTS The absorption rate constants(Ka) of tilianin in total Dracocephalum flavones were 5. 7651 × 10^-2.4. 4081 × 10^-2 .4. 3873 ×10^-2.3. 9899 × 10^- 2 at colon, jejunum, duodenum and ileum respectively; and Ka of tilianin were 6. 7897 × 10^-2.6. 3018 × 10^-2.5. 8011×10^- 2.5. 6765 × 10^-2 at duodenum, ileum, jejunum and colon respectively. CONCLUSION The absorption characteristics of tilianin at small intestine segments has no difference with tilianin in the flavones.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2011年第20期1667-1670,共4页
Chinese Journal of Hospital Pharmacy
基金
国家自然科学基金(编号:8116025)
关键词
香青兰总黄酮
田蓟苷
吸收动力学
大鼠小肠单向灌流
Dracocephalum total flavones
tilianin
absorption kinetic
in situ perfused rat intestinal modal