新辅助化疗对中、晚期宫颈癌临床疗效观察

Clinical effect of neoadjuvant chemotherapy on the middle and advanced cervical cancer

目的探讨新辅助化疗在宫颈癌中、晚期放疗中的应用价值。方法选择2005年1月～2009年10月在我院治疗的中、晚期宫颈鳞癌Ⅱb～Ⅲb患者100例,随机分为两组:新辅助化疗和放疗组50例,单纯放疗组50例,两组放疗方法相同,新辅助化疗后放疗组患者在放疗前先用顺铂+多西紫杉醇化疗1～2个疗程,化疗结束后1周开始放疗。比较两组患者近期有效率及不良作用。结果新辅助化疗和放疗组比单纯放疗组近期疗效分别为94%及72%(P<0.05)。两组骨髓抑制及消化道反应经处理后均能恢复。结论新辅助化疗对宫颈癌的治疗是安全有效的,能明显提高近期疗效。特别是对于宫颈癌中、晚期患者疗效更佳。

Objective To investigate the application value of neoadjuvant chemotherapy for radiotherapy in the middle and advanced cervical cancers.Methods 100 patients with Ⅱ b～Ⅲ b cervical squamous cell carcinomas during January 2005 to October 2009 in our hospital were randomly divided into two groups,the neoadjuvant chemotherapy group and the radiotherapy group,50 cases in each.The radiotherapy was the same in the two groups.In addition,the patients in the neoadjuvant chemotherapy group treated with 1～2 course of cisplatin and docetaxel 1 week before the following radiotherapy.The immediate effects and side effects in the two groups were analyzed.Results The immediate effects in the neoadjuvant chemotherapy group and in the radiotherapy group were 94% and 72%（P〈0.05）.The bone marrow suppression and gastrointestinal symptoms in the two groups could resume after the Corresponding treatments.Conclusion Neoadjuvant chemotherapy is safe and effective for cervical cancers,and it could significantly improve the immediate effects,especially better for the middle and advanced cervical cancer patients.