前列地尔治疗慢性心功能不全患者血浆脑钠肽的疗效研究

Research on the Effect of PGE1 for the Serum Levels of BNP in Patients with Chronic Heart Failure

目的动态观察前列地尔(PGE1)治疗慢性心功能不全患者(CHF,简称心衰)血浆脑钠肽(BNP)的影响。方法慢性心衰患者72例,随机分为对照组(36例)和治疗组(36例)。对照组给予常规药物治疗。治疗组在CHF常规治疗的基础上加用(PGE1)20μg/d,共14 d,观察治疗前和治疗后7、14d各组患者血浆脑钠肽(BNP)水平。结果与治疗前相比,治疗后两组血浆BNP水平均明显改善(P<0.05),对比每一时间位点治疗组改善更为明显。结论前列地尔可有效辅助治疗慢性心衰,改善心功能。

Objective To observe the effect of PGE1 on the serum levels of BNP in patients with CHF.Methods 72 patients with CHF were randomly separated into two groups.36 patients in control group were given routine therapy,36 patients in treatment group were given routine thempy and 20μg PGE1 once daily for 2 weeks.The serum levels of BNP were measured before therapy and after therapy（the seven and fourteen days）.Results The serum levels of BNP was significantly improved after two weeks of therapy in two groups（P0.05）,especially in treatment group.Conclusion PGE1 is effective for the assistant treatment of CHF,and can improve cardiac function,shorten the day of disease.