替罗非班对急性心肌梗死患者经皮冠状动脉介入治疗术后抗炎、促炎因子的影响

Impact analysis of Tirofiban to the anti-inflammatory and pro-inflammatory factors in patients with acute myocardial infarction after PCI

目的:研究急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后应用替罗非班对抗炎因子和促炎因子的影响。方法:选择2009年10月～2010年12月我院行PCI的急性心肌梗死患者95例,将其分为常规治疗组(n=54)和替罗非班组(n=41),两组分别测定术前1 h、术后24 h血清IL-6、IL-10、P-选择素和C反应蛋白(CRP)含量。结果:常规治疗组PCI术后仅IL-6降低(t=2.132,P=0.046),其他指标均未见明显变化。而替罗非班组术后IL-6(t=4.315,P=0)、CRP(t=2.970,P=0.005)和P-选择素(t=3.308,P=0.002)均较治疗前及常规治疗组显著下降;IL-10上升明显,差异有统计学意义(t=2.424,P=0.020)。结论:替罗非班可抑制血小板聚集,降低促炎因子释放,大大降低PCI术后并发症。

Objective： To study the effect of Tirofiban to the anti-inflammatory and pro-inflammatory factors in patients with acute myocardial infarction（AMI） after PCI.Methods： 95 patients with AMI treated by percutaneous coronary intervention（PCI） in our hospital from October 2009 to December 2010 were selected and divided randomly into conventional treatment group（n=54） and Tirofiban group（n=41）.The level of IL-6,IL-10,P-selectin and CRP of serum were measured.Results： The level of IL-6 in the conventional treatment group decreased obviously after PCI（t=2.132,P=0.046）,whereas other index had no significant changes.The level of IL-6（t=4.315,P=0）,CRP（t=2.970,P=0.005） and P-selectin（t=3.308,P=0.002） in Tirofiban group decreased remarkably compared with fore-treatment and routine group.The level of IL-10 increased obviously（t=2.424,P=0.020）,the difference was statistically significant.Conclusion： Tirofiban can inhibit of platelet aggregation,reduce the release of pro-inflammatory factors and lower the complications of PCI.