2LOUGHLIN J,IRVEN C,FERGUSSON C,et al.Sibling pair analysis shows no linkageof generalized OA to the loci encoding typeⅡ collagen,cartilage link protein or cartilage matrix protein[J].Br J Rheumatol,1994,33(11):1103- 1106.
3BLEASEL JF,HOLDERBAUM D,MALLOCK V, et al.Hereditary OA with mild spondyloepiphyseal dysplasia are there "hot spots" on COL2A1[J].J Houmatol,1996,239(9):1594- 1598.
4FERTALA A,KOKKO LA,WIADERKREWICR R, et al.Collagen Ⅱ containing a Cys substituation for Arg- α 1 519[J].J Bio Chem,1997,272(10):6457- 6464.
5PROCKOP DJ,WILLIAMS CJ,VANDENBERG P.Collagen in normal and diseaseconnective tissue[A]//MCCARTY DJ,KOOPMAN WJ.A rthritis and Allied Conditions ed 12[M]. Philadelphia:Lee and Febig er,1993:213- 227.
6VIKKULA M,PALOTIE A,RITRANIEMI P,et al.Early onset OA lin ked to the type Ⅱ procollagen gene[J].Arthritis Rheum,1993,36(3):401- 409.
7CICUTTINI FM,SPECTOR TD.Genetics of osteoarthritis[J].Ann Rheum Dis, 1996,55(8):665- 676.
8RITVANIEMI P,KORKKO J,BONAVENTURE J, et al.Identification of COL2A1 gene mutations in patient with chondrodysplasias and familial OA[J].Arthritis Rheum,1995,38(7):999- 1004.
9AKHURST RJ.Prospectos for gene therapy[J].Rheumatology Review, 1992,1(2):113- 121.
10RYAN LM,MCCARRY DJ.Calcium pyrosphosphate crystal deposition disease:pseudogout; articular chondrocalcinosis[A]//MCCARRY DJ,KOOPMAN WJ. Arthritis and allied conditions[M].12th ed. Philadelphia:Lea and Febiger,1993:1835- 1855.
