基于层次聚类分析与数据图形化技术探讨少腹逐瘀汤与温经汤的组方配伍特点

Explore the combination relationship of Shaofu Zhuyu Decoction and Wenjing Decoction based on hierarchical clustering analysis and data visualization technology

目的:研究少腹逐瘀汤与温经汤的配伍特点,为治疗妇科瘀血腹痛提供治疗思路及理论依据。方法:对少腹逐瘀汤与温经汤组方药物的药性信息进行量化处理,采用层次聚类分析法、数据图形化技术分别对两方组方特点进行分析。结果:聚类分析结果表明:少腹逐瘀汤10味药物根据其性、味、归经属性聚类为当归、肉桂、小茴香与干姜;没药与延胡索;蒲黄与五灵脂;赤芍与川芎4组。温经汤12味药物聚类为生姜、半夏、吴茱萸与当归;人参、麦冬与甘草;芍药;阿胶、牡丹皮、桂枝与川芎4组。图形化分析结果显示:在归经上,少腹逐瘀汤主要分布在脾(胃)、肝(胆)、心(小肠)经,而温经汤主要分布在脾(胃)、肺(大肠)、肝(胆)、肾(膀胱)经,脾(胃)、肝(胆)两组经络均为两方的重要分布区域;在味的分布上,辛、甘、苦3味是两方共同的重点分布区。体现了少腹逐瘀汤以温经散寒止痛配伍活血祛瘀药,针对少腹瘀血腹痛的病机,而温经汤则寒温消补并施,升降相调,更注重从整体角度调制的用药特点。结论:多种数据挖掘分析方法联用能够更加客观的分析评价中医方剂配伍关系及其用药特点,为妇科瘀血腹痛病症的治疗及方剂现代研究提供参考。

Objective： To explore the combination relationship of Shaofu Zhuyu Decoction（SFZYD） and Wenjing Decoction（WJD） based on the methods of hierarchical clustering analysis and data visualization in order to provide guidance for modern research of the formula.Methods： The data mining technology based on the hierarchical clustering analysis and data visualization was used to analysis the complicated correlations of Shaofu Zhuyu decoction and Wenjing Decoction after qualitative information of drugs property.Results： The analytic results stated that the drugs in SFZYD were classified four clusters of Danggui-Rougui-Xiaohuixiang-Ganjiang,Moyao-Yuanhu,Puhuang-Wulingzhi,and Chuanxiong-Chishao.WJD were classified four clusters of Shengjiang-Banxia-Wuzhuyu-Danggui,Renshen-Mandong-Gancao,Shaoyao,and Ajiao-Danpi-Guizhi-Chuanxiong.The graphic models of Xing,and Wei,and Guijing stated that the properties of drugs in SFZYD are mainly distribute in warm and hot scope,but the properties of drugs in WJD are distributed in two scopes;About the Guijing,the drugs of SFZYD fasten on Pi（Wei）,Gan（Dan）,Xin（Xiaochang）,while the drugs of WJD fasten on Pi（Wei）,Gan（Dan）,Fei（Da chang）,Shen（Pangguang）.The Pi（Wei） and Gan（Dan） channels are the important distribution areas.The pungent,sweet and hard are the major taste.Conclusion： The results are agreeing with the theory of TCM and provide guidance for modern research of TCM formulae.The multi-mathematical analysis methods may be feasible for research the complex correlations.