培哚普利联合吲达帕胺治疗高血压合并糖尿病肾病疗效观察

Clinical effects of perindopril combined with indapamide in the treatment of hypertension compilicated by diabetic nephropathy

目的探讨培哚普利和吲达帕胺联合应用于高血压合并糖尿病肾病患者的临床疗效与安全性。方法选取高血压合并糖尿病肾病的患者90例,给予吲达帕胺25mg/d、培哚普利4mg/d进行治疗,疗程为12周。采用自身对照实验,比较治疗前后血压和肾功能的变化情况。结果治疗结束后患者的血压水平较治疗前明显下降(P<0.05),患者尿β-MG与24h尿蛋白较治疗前显著下降(P<0.05)。结论培哚普利和吲达帕胺联合应用于高血压合并糖尿病肾病患者有较好的降血压作用,能降低微量尿蛋白,改善高血压合并糖尿病患者早期肾功能的损害。

Objective To study the clinical efficacy and safety of perindopril combined with indapamide in the treatment of hypertension complicated by diabetic nephropathy.Methods 90 patients with hypertension and diabetic nephropathy were given indapamide 25 mg/d,perindopril 4 mg/d for 12 weeks.The changes of blood pressure and renal function before and after treatment were compared.Results After treatment,the levels of blood pressure significantly decreased than that before treatment（P〈0.05）,and the levels of urine β-MG,and 24 hour urine protein decreased significantly（P〈0.05）.Conclusion The application of perindopril combined with indapamide for treating hypertension and diabetic nephropathy shows good effect in lowering blood pressure,and can reduce the trace urine protein as well as improve early renal damage of patients.