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亚低温高容量血液滤过治疗严重颅脑损伤后多器官功能障碍

Study of Mild-hypothermia High-volume Hemofiltration for the Treatment of Multiple Organ Dysfunction after Severe Brain Injury
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摘要 [目的]探讨亚低温高容量血液滤过(HVHF)治疗严重颅脑损伤后多器官功能障碍患者的预后及与肿瘤坏死因子(TNF-α)、白介素-1(IL-1)、白介素-10(IL-10)水平的变化.[方法]无肝素化HVHF治疗重度颅脑损伤MOD患者,监测14 d患者病死率及监测患者治疗前、治疗后24 h、48 h TNF-α、IL-1、IL-10变化.[结果]血液滤过治疗24 h及48 h的TNF-α、IL-1、IL-10水平明显低于血滤治疗前.治疗14 d后治疗组病死率明显低于对照组.[结论]亚低温HVHF治疗严重颅脑损伤后MOD患者,能够降低炎症介质、改善其预后. [Objectivel To explore the prognosis of patients with multiple organ dysfunction patients after severe brain injury treated by mild-hypothermia high-volume hemofiltration and the changes of tumor necrosis factor-alpha(TNF-α), interleukin-l(IL-1) and interleukin-10(IL-10). [Methods] Severe brain injury patients with multiple organ failure were treated with non-heparinized hemofiltration. The mortality 14 days after treatment and the changes of TNF-a, IL-1 and IL-10 at 24 hours and 48 hours before and after treatment were monitored. [Results] The levels of TNF-a, IL-1 and IL-10 at 24 hours and 48 hours after hemofiltration were obviously lower than those before hemofiltration. The mortality 14 days after hemofiltration in treatment group was obviously lower than that in control group; [Conclusion] Mild-hypothermia high-volume hemofiltration for the treatment of the patients with multiple organ dysfunction after severe brain injury can reduce the inflammatory mediators to improve their prognosis;
作者 周秀华 刘丹
出处 《医学临床研究》 CAS 2011年第9期1633-1634,共2页 Journal of Clinical Research
基金 辽宁省沈阳市科学基金项目(1091172-1-04)
关键词 脑损伤/并发症 多器官功能衰竭/治疗 低温 血液过滤 brain injuries/CO multiple organ failure/TH hypothermia hemofiltration
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