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内皮功能障碍、ET-1、KL-6与OSAHS关系的研究进展 被引量：6

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摘要 阻塞性睡眠呼吸暂停低通气综合征（Obstructive sleep apnea-hypopnea syndrome,OSAHS）因其心脑血管并发症越来越受到医患双方的重视,其中血管内皮损伤近年来研究得比较多.国内外学者研究[1,2]证明OSAHS患者存在持续性的血管内皮细胞（vascular endothelial cell,VEC）损伤,与病程后期的心脑血管事件紧密相关.Sanja Jelic等[3]发现在排除掉肥胖、代谢异常等混杂因素后单纯OSAHS患者仍存在VEC损伤,表现为VEC修复功能降低,凋亡加快.不仅是成人,小儿OSAHS引起高心血管发病率和代谢障碍也见报道[4],尤其是肥胖小儿,与成人不同的是重度OSAHS患儿的VEC功能改变多可逆,后者介导阻塞后期的充血反应.本文主要从内皮细胞损伤机制及损伤后表现两个方面,对其作一简要综述.
作者 邓晓雯（综述） 冯晓辉（审校）
机构地区 南华大学医学院 湖南师范大学第一附属医院暨湖南省人民医院耳鼻咽喉头颈外科
出处 《医学临床研究》 CAS 2011年第9期1770-1773,共4页 Journal of Clinical Research
关键词 睡眠呼吸暂停综合征 内皮 血管 内皮缩血管肽类 糖蛋白类 综述文献
分类号 R563.8 [医药卫生—呼吸系统]
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参考文献25

  • 1Chang-Ho Yun,Keun-Hwa Jung,Kon Chu,et al.Increased circulating endothelial microparticles and carotid atherosclerosis in obstructive sleep apnea[J].J Clin Neurol,2010,6(1):89-98.
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二级参考文献55

  • 1林岫芳,陈剑,周智娟.心血管疾病与睡眠呼吸暂停综合征的相关研究[J].中华流行病学杂志,2004,25(8):654-654. 被引量：17
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共引文献23

同被引文献117

引证文献6

二级引证文献38

医学临床研究
2011年 第9期

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