焦虑综合征对女性急性冠脉综合征的影响

The influence anxiety syndrome to female patients with acute coronary syndrome

目的本研究选定女性急性冠脉综合征(ACS)患者这一特定人群,通过检测血清IL-6和CRP的水平,探讨焦虑综合征对ACS的影响,为临床干预焦虑综合征提供试验依据。方法根据贝克焦虑量表将研究对象分为焦虑综合征组51例与非焦虑综合征组49例。量表评分≥45分为焦虑综合征组。对比2组血清IL-6、CRP水平;随访1月,比较2组心血管不良事件的发生率。结果焦虑综合征组血清IL-6和CRP水平显著高于非焦虑综合征组,IL-6为(101.1±22.3)ng/Lvs(71.2±23.5)ng/L,CRP为(14.90±4.86)g/Lvs(6.76±4.02)g/L,2组相比具有显著性差异(P<0.05)。焦虑综合征组中贝克焦虑量表评分与IL-6和CRP水平呈正相关(IL:r=0.887,CRP:r=0.822,P均<0.001)。焦虑综合征组不良心血管事件发生率显著高于非焦虑综合征组(64.71%vs28.57%),2组相比具有显著性差异(P<0.01)。结论女性ACS合并焦虑综合征患者的血清IL-6和CRP水平显著升高,焦虑量表评分与血清IL-6和CRP水平呈正相关。女性ACS合并焦虑综合征患者的心血管不良事件的发生率高。女性ACS合并焦虑综合征患者发生高频率的不良心血管事件可能与血清炎症因子水平IL-6和CRP水平升高有关。

Objective To investigate the relationship between anxiety syndrome and inflammatory factor,in order to provide doctors with experimental basis for their potency evaluation.Methods All patients were divided into 2 groups,one group with anxiety syndrome and the other group without.The serum levels of IL-6 and CRP were determined in patient with acute coronary syndrome,cardiovascular events were observed in every group.Results The serum levels of IL-6 and CRP in the group with anxiety was（101.1±22.3）ng/L and（14.90±4.86）g/L.The serum levels of IL-6 and CRP in the other group was（71.2±23.5）ng/L and（6.76±4.02）g/L.The difference between the two groups had statistic significance（P0.05）.In the group with anxiety the levels of beke were along with the serum levels of IL-6（r=0.881） and CRP（r=0.822）.The rate of cardiovascular events in the group with anxiety was 64.71%,the rate of cardiovascular events in the other group was 28.57%.The difference between the two groups had statistic significance（P0.01）.Conclusion The serum levels of IL-6 and CRP in group with anxiety syndrome is higher,in the group with anxiety the levels of beke are along with the serum levels of IL-6 and CRP.The cardiovascular events in group with anxiety syndrome is higher.Anxiety syndrome may affect the prognosis of acute coronary syndrome through the serum levels of IL-6 and CRP.