hs-CRP联合颈动脉斑块检测对冠心病的预测意义

Study on relativity of hs-CRP and carotid artery Plaque in patients with coronary heart disease

目的探讨高敏C反应蛋白(hs-CRP)联合颈动脉斑块对冠心病的预测价值。方法将140例观察对象分为对照组30例、稳定型心绞痛组(SA组)40例、急性冠脉综合征(ACS)组70例[不稳定型心绞痛组(UA组)50例和急性心肌梗死组(AMI组)20例],所有患者均行体表颈动脉超声检查(包括颈动脉内膜中层厚度、斑块情况)、冠脉造影和血清高敏C反应蛋白(hs-CRP),比较3组患者颈动脉斑块情况、冠状动脉病变情况及血清高敏C反应蛋白(hs-CRP)水平。结果与对照组相比,冠心病组患者颈动脉斑块发生率较高;ACS组hs-CRP水平明显高于SAP组和对照组。结论 hs-CRP水平有助于冠状动脉内不稳定斑块的预测;颈动脉斑块有助于冠脉斑块的预测,颈动脉斑块联合hs-CRP对急性冠脉综合征有一定的预测意义。

Objective To study the predictive value of serum levels of high sensitivity C-reactive protein （hs-CRP） and carotid artery plaque in patients with coronary heart disease. Methods 140 patients were classified into three groups： control group（30 patients）, stable angina group（40 patients） and ACS group（70 patients）, ACS group were classified into unstable angina group （50 patients） and acute myocardial infarction group （20 patients）. All patients were examined by carotid ultrasound respectively and to observe their characteristics of carotid atherosclerosis （including IMT, plaque and its character）, CAG and hs-CRP. Results Incidence of plaques of carotid arteries were detected in patients with coronary heart disease was higher than control group. The serum level of hs-CRP in ACS were increased significantly compared with stable angina group and control group. Conclusion The level of hs-CRP could help to select and diagnose unstable atherosclerotie plaque in coronary artery. The plaques of carotid artery could help diagnose the plaques of coronary artery. The level of hs-CRP and carotid artery ultrasound can early predicted the patients with acute coronary syndromes.