摘要
头孢西丁钠是一种具有长效、广谱抗菌特点的第二代头孢类抗生素。通过对头孢西丁钠原料药结晶工艺进行筛选,调节头孢西丁钠的pH值、加稳定剂、改变残氧量及不同的结晶状态,使其稳定性得到改善,收率为95%左右。
Cefoxitin sodium,the second-generation cephalosporins,is permanence and has a broad spectrum of antibacterial activity.To study the stability of the product.Through choosing of crystallization technology of the API cefoxitin sodium,adjusting pH value,adding stabilizer,changing remind oxygen and crystallization condition,the drug stability has been improved,the yield reached about 95%.
出处
《河北化工》
2011年第10期14-15,共2页
Hebei Chemical Industry
关键词
头孢西丁钠
稳定性
PH值
残氧量
结晶
cefoxitin sodium
stability
pH value
remind oxygen
crystallization
