以CD4^+T淋巴细胞为依据探索云南省红河州中医药治疗HIV/AIDS人群的最佳时机

Exploration of the Best Time for HIV/AIDS Persons with Traditional Chinese Medical Treatment of Yunnan Provinceon the Basis of CD4^+T lymphocytes

目的:通过分析中医药治疗的HIV/AIDS患者的疗效及其影响因素,探索中医药治疗HIV/AIDS的最佳CD4+T淋巴细胞水平,以此为依据,提供在国内或更为广泛的地区开展相应治疗。方法:从在红河州中医医院2005年6月~2008年9月间,进行单纯中医药治疗满12个月的HIV/AIDS患者中,选取临床资料完整的患者116例,从年龄、性别、感染途径、用药及入组时CD4+T淋巴细胞水平等几个因素,分析治疗后,上述诸原因对CD4+T淋巴细胞的影响。结果:不同年龄、性别、感染途径这几个因素,经治疗后,对CD4+细胞升降有效率均无显著差异;入组CD4+T淋巴细胞计数<350个/μL的患者有效率显著高于入组CD4+T淋巴细胞计数≥350个/μL者。入组CD4+T淋巴细胞计数与治疗有效率存在中度负相关。结论:性别、年龄、感染途径与中医药治疗对CD4+疗效无显著关联;入组CD4+T淋巴细胞计数与中医药治疗对CD4+疗效有显著关联。CD4+T淋巴细胞计数<350个/μL是中医药治疗的最佳时机。

Objective:To explore the best level of CD4+T lymphocytes of HIV/AIDS persons through the analysis of the efficacy and the influencing factors of traditional Chinese medicine and provide more extensive treatment throughout the country. Methods:116 HIV/AIDS persons were selected from the patients who received a 12-month treatment of traditional Chinese medicine in Honghe Prefectural Hospital of Traditional Chinese Medicine from June,2005 to September,2008. The impact of CD4+T lymphocytes was analyzed after the treatment from the age,the gender,the infected way,medication and the original CD4+T cell levels of the patients. Results:Different age,sex and infected way showed no significant difference after the treatment in the promotion and demotion of CD4+ cells. The effective rate of the patients in CD4+T lymphocyte count <350/μL group was significantly higher than that of the patients in CD4+T lymphocyte count ≥350/μL group. The cell count of the patients in the CD4+T lymphocyte groups had moderate negative correlation with the treatment efficiency. Conclusion:The gender,the age and the infection route have no significant association with CD4+ medical efficacy. The cell count of the patients in the CD4+T lymphocyte groups is significantly associated with the CD4+ medical efficacy. CD4+T lymphocyte count <350/μL is the best time for the patients with the traditional Chinese medical treatment.