勃脉力A注射液对肝叶切除患者肝功能的影响

目的探讨勃脉力A注射液对肝叶切除术患者肝功能的影响。方法选取在普外科行肝叶切除术患者64例,随机分为勃脉力A注射液组(P组)和乳酸钠林格氏液组(R组)。P组补充晶体液为勃脉力A注射液,R组为对照组,补充晶体液为乳酸钠林格氏液。两组患者均在术前30min内输完液体剂量为15ml/kg,术中再根据CVP输入液体。所有患者均在术前(T0)、术后1d(T1)、3d(T2)、7d(T3)分别采中心静脉血和桡动脉血:静脉血分离血清后检测血清中天冬氨酸转氨酶(AST)、丙氨酸氨基转移酶(ALT)值及总胆红素(TB)、白蛋白(ALB),以了解患者的肝脏功能改变;抽取动脉血检测乳酸(Lac)浓度。结果与R组相比较,在术后各时间点P组ALT、AST及乳酸浓度均显著降低(P<0.05)。结论勃脉力A注射液组患者术后肝功能恢复明显快于乳酸钠林格氏液组,并且能够有效降低乳酸浓度,适用于肝叶切除手术的患者。

Objective To study the effect of plasmaslyte A on liver function for resection of liver. Methods 64 patients programmed for liver resection randomized to receive plasmaslyte A（group P, n=32） and ringer lactate solution （group R, n=32）. The two fluids were used during operation. All groups were measured for the level of AST.ALT.TB.ALB and Lac at -1 day, 1, 3 and 7 days after surgery. Results The level of ALT.AST and Lac in P group were significantly lower than those in R group after operation（P〈0.05）. Conclusion Plasmaslyte A can reduce availablyly the level of AST. ALT and Lac, and plays its protective role during liver resection.