复发转移乳腺癌患者血清HER2水平与组织表达状态的相关性

The Correlation between Serum HER2 Level and Expressions of HER2 in Tissues in Patients with Recurrent Metastatic Breast Cancer

目的探讨复发转移乳腺癌患者血清HER2水平与组织表达状态间的联系,分析血清HER2检测是否可作为组织HER2检测的补充手段。方法采用酶联免疫吸附试验(ELISA)对72例女性复发转移乳腺癌(组织HER2阳性组30例,组织HER2阴性组42例)和30例健康体检女性(健康对照组)进行血清HER2水平检测,将各组的血清HER2水平进行比较,并与组织HER2表达状态进行对比分析。结果组织HER2阳性组的血清HER2水平显著高于组织HER2阴性组和健康对照组,差异有统计学意义(P<0.0001);组织HER2阴性组血清HER2水平与健康对照组比较差异无统计学意义(P=0.163);组织HER2阳性组有22例血清HER2阳性,阳性符合率为73.4%(22/30),组织HER2阴性组有32例血清HER2阴性,阴性符合率为78.6%(32/42)。血清HER2水平与组织HER2表达状态呈正相关(χ2=21.626,r=0.547)。结论血清HER2水平与组织HER2表达状态呈正相关,且血清HER2可以作为组织HER2检测的补充手段。

Objective To study the relationships between serum HER2 level and tissue HER2 status and analyze the possibility of serum HER2 being complementary to tissue HER2 detection in recurrent metastatic breast cancer patients.Methods 72 recurrent metastatic breast cancer patients（30 patients in tissue HER2-positive group,42 patients in tissue HER2-negative group） and 30 healthy women（healthy control group）were enrolled in the study,and the serum HER2 level were detected by ELISA and were compared with HER2 expression in tissues.Results The serum HER2 level was significantly higher in tissue HER2-positive group than in that in tissue HER2-negative group and healthy control group,and the differences were significant（P0.0001）;there was no difference between tissue HER2-negative group and healthy control group（P=0.163）;Serum HER2 was positive in 22 patients in tissue HER2-positive group and the positive accordance rate was 73.4%（22/33）;Serum HER2 was positive in 22 patients in tissue HER2-negative group and the negative accordance rate was 78.6%（32/42）.Serum HER2 was positively related to tissue HER2（χ2=21.626,r=0.547）.Conclusion The serum HER2 is positively related to tissue HER2 status,which can be taken as a complementary method to tissue HER2 detection.