基于SIRT1靶点的非酒精性脂肪肝研究进展

Research Progress of the Nonalcoholic Fatty Liver Based on the SIRT1 Target Spot

脂肪肝是由各种原因引起的肝细胞内脂肪堆积过多的病变。它可分为酒精性脂肪肝和非酒精性脂肪肝(NASH)两大类,其中人群中又以NASH最为多见。沉默信息调节因子1(SIRT1)是在哺乳动物细胞中发现的与酵母沉默信息调节因子2同源性最高的同系物。研究发现SIRT1不仅参与了细胞的能量代谢,而且还能通过各种途径改善胰岛素的敏感性、调节脂质代谢、减轻炎性反应和氧化应激损伤。因此,其可能成为NASH治疗的新靶点及寻找新一代NASH防治新药的重要途径。

Pathological changes due to various reasons leading to excessive fat accumulation in the hepatic cell is called fatty liver,which can be classified into two categories：alcoholic fatty liver and nonalcoholic steatohepatitis（NASH） which is common in the multitude.Discovered in the cells of the mammal,silent information regulator1（SIRT1）is a homolog,which has the highest homology with the silent information regulation factor 2 of the yeast.SIRT1 not only participates in the energy metabolism,but is also able to improve the insulin sensitivity,adjust the lipid metabolism relieve the inflammatory response and the oxidative stress damage.Therefore,it may become the new target spot to treat NASH and an important way to find a new generation of drugs to prevent and control NASH.