期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

增殖细胞核抗原在涎腺腺样囊性癌中的表达及其临床意义 被引量：2

下载PDF
导出
摘要 目的探讨增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)在涎腺腺样囊性癌(salivary adenoid eystic car-cinoma,SACC)中的表达及其临床意义。方法 32例SACC石蜡包埋标本,用免疫组织化学方法(SABC)测定。结果 PCNA在SACC中的表达阳性率为(75.17±21.28)%,表达呈异质性。PCNA指数与SACC的病理类型、淋巴结转移、肿瘤部位及临床分期密切相关。结论 PCNA可作为判断SACC恶性程度及预后的指标。
作者 李晓光 卢会青 刘敏 王延秀 李腾宇
机构地区 山东省泰安市中心医院口腔科 山东省泰安市中心医院手术室 山东省泰安市中心医院麻醉科 青岛大学医学院口腔系
出处 《重庆医学》 CAS CSCD 北大核心 2011年第29期2969-2971,共3页 Chongqing medicine
基金 泰安市科技局资助项目(2007-46)
关键词 免疫组织化学 增殖细胞核抗原 涎腺腺样囊性癌
分类号 R739.8 [医药卫生—肿瘤]
  • 相关文献

参考文献9

  • 1Tincani AJ,Del Negro A,Araujo PPC,et al.Management of salivary gland adenoid cystic carcinoma:institutional experience of a case series[J].Sao Paulo Med J,2006,124(1):26-30.
  • 2Bravo R,Frank R,Blandell PA,et al.Cyclin/PCNA is the auxiliary protein DNA polymerase-delta[J].Nuture,1987,326(6112):515-517.
  • 3Hsieh TC,Burfeind P,Laud K,et al.Cell cycle effects and control of gene expression by resveratrol in human breast carcinoma cell lines with different metastatic potentials[J].Int J Oncol,1999,15(2):245-252.
  • 4Ng IO,Lai EC,Fan ST,et al.Prognostic significance of proliferating cell nuclear antigen expression in hepatocellular carcinoma[J].Cancer,1994,73(9):2268-2274.
  • 5周人杰,陈伟,闵家新,张国强,戴纪纲,肖颖彬.ICAM-1和PCNA在肺癌中的表达及其意义[J].重庆医学,2007,36(18):1834-1835. 被引量：2
  • 6李晓川,王严庆.MMP_2、MMP_9和PCNA在大肠肿瘤中的表达及临床意义[J].重庆医学,2003,32(7):870-872. 被引量：10
  • 7Nordstrom B,Strang P,Bergstrom K,et al.A comparison of proliferating markers and their prognostic value for women with endometrial carcinoma[J].Cancer,1996,78(9):1942-1942.
  • 8Woods AL,Hanby AM,Hall PA,et al.The prognostic value of PCNA (Proliferating cell nuclear antigen immunostaining in gastrointestinal lymphomas[J].J Pathol,1990,161:342-351.
  • 9李晓光,于肖鹏,赵海兰,闫利勇,王俊峰,王延秀.PCNA在口腔鳞癌中的表达及其临床意义[J].泰山医学院学报,2005,26(1):20-22. 被引量：5

二级参考文献28

  • 1丛文铭,吴孟超.小肝细胞癌的临床病理特点：附93例分析[J].中华肿瘤杂志,1993,15(5):372-374. 被引量：35
  • 2Shimizu M, Saitoh Y, Itoh H. Immunohistochemical staining of Ha-ras oncogene product in normal, benign,and malignant human pancreatic tissues [J ]. Hum Pathol, 1990, 21: 607.
  • 3Hoyhtya M, Hujanen E, Jurpeenniemi-Hujanen J, et al.Modulation of type IV collagenase activity and invasive behavior of metastatic human melanoma (A2058) cells in vitreo by monoclonal antibodies to type IVcollagenase[J].Int J Cancer, 1990, 46(2) : 282.
  • 4Ballin M, Gomez DE, Sinha CC, et al. Ras oncogene mediated induction of a 92 Kda metalloproteinase: strong correlation with the malignant phenotype [J]. Biochem Biophs RES Commun, 1988, 154(3) : 832.
  • 5Grigioni WF, DErrico A, Fortunato C, et al. Prognosis of gastric carcinoma revealed by interactions between tumor cells and basement membrane[J]. Mod Pathol,1994, 7(2): 220.
  • 6Tomita T,Iwata K. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in colonic adenomas-adenocarcinomas [J]. Dis Colon Rectum, 1996, 39 (11) :1255.
  • 7Ring P, Johansson K, Hoyhtya M,et al. Expression of tissue inhibitor of metalloproteinase TIMP-2 in human colorectal cancer-a prediction of tumor stage[J]. Br J Cancer, 1997, 76(6): 805.
  • 8Maeda K,Chung Y,Onoda N,et a1.Proliferating cell nuclear antigen labeling index of preoperative biopsy specimens in gastric carcinoma with special reference to prognosis[J].Cancer,1994,73(3):528.
  • 9Bravo R, Blandell PA, et al.Cyclin/PCNA is the auxiliary protein DNA polymerase apha[J].Nuture,1987,326:515.
  • 10Hsieh TC, Burfeind P, Laud K, et al.Cell cycle effects and control of gene expression by resveratrol in human breast carcinoma cell lines with different metastatic potentials[J].Int J Oncol, 1999, 15(2): 245-252.

共引文献14

同被引文献26

  • 1邱蔚六.口腔颌面外科学[M].第6版.北京:人民卫生出版社,2009:231.
  • 2Weidner N, Semple JP, Welch WR, et al. Tumor angiogenesis and metatasis-correlation in invasive breast carcinoma [J]. New Engl J Med, 1991, 324(1): 1-8.
  • 3Usman Saeed M, Batra R, Qureshi F, et al. Reflux of drug during intra-vitreal anti-VEGF therapies [J]. Semin Ophthalmol, 2011, 26(6): 357-360.
  • 4Ueta T, Mori H, Kunimatsu A, et al. Stroke and anti-VEGF therapy[J]. Ophthalmology, 2011, 118(10): 2093-2093.e2.
  • 5Im SA, Gomez-Manzano C, Fueyo J, et al. Antiangiogenesis treatment for gliomas: transfer of antisense-vascular endothelial growth factor inhibits tumor growth in vivo [J]. Cancer Res, 1999, 59(4): 895-900.
  • 6Bruns C J, Liu W, Davis DW, et al. Vascular endothelial growth factor is an in viva survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases[J]. Cancer, 2000, 89(3): 488-499.
  • 7Bachelder RE, Crago A, Chung J, et al. Vascular endothelial growth factor is an autocrine survival factor for neuropilin- expressing breast carcinoma cells [J]. Cancer Res, 2001, 61(15): 5736-5740.
  • 8Bravo R, Frank R, Blundell PA, et al. Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta [J]. Nature, 1987, 326(6112): 515-517.
  • 9Hsieh TC, Burfeind P, Laud K, et al. Cell cycle effects and control of gene expression by resveratrol in human breast carcinoma cell lines with different metastatic potentials [J]. Int J Oncol, 1999, 15(2): 245-252.
  • 10Martinez LA, Naguibneva I, Lehrmann H, et al. Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways [J].Proc Natl Acad Sci USA,2002,99(23): 14849-14854.

引证文献2

二级引证文献2

重庆医学
2011年 第29期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部