摘要
本文用HPLC法测定环孢素的全血浓度,对8例异体肾移植病人口服环孢素后的药代动力学特性进行研究。病人在肾移植后用环孢素的时间为47天到11个月,平均给药剂量为8.26±1.41 mg/kg·d(5.88～10.0mg/kg·d),每12h一次。病人常规监测血样本300余次。测得病人的环孢素药代动力学参数:峰浓度(Cmax)664.9±87.5 ng/ml,达峰时间(Tmax)3.27±1.07h;t^(2/2)β13.53h(6.13～44.3h)。
Cyclosporine was extracted from whole blood and analyzed by HPLC. The pharmacokinetics of oral cyclosporine were studied in patients with renal transplant. They were 5 women and 3 men between the ages of 29～49 years. Cyclosporine was used for 47 days to 11 months after renal transplantation. The mean dose was 8.26±1.41 mg/kg. d (5.88～10.0 mg/kg.d), once each 12 hours. Three hundreds whble blood samples were monitored. The peak concentration (C_(max)) was 664.9±87.5 ng/ml; peak time was 3.27±1.07 h; slow elimination phase t_(1/(2β)) was 13.53 (6. 13～43.3) h.
出处
《药学学报》
CAS
CSCD
北大核心
1990年第1期1-5,共5页
Acta Pharmaceutica Sinica
