大籽獐牙菜中大籽獐牙菜甙的结构

STRUTCTURE OF SWERTIAMACROSIDE FROM SWERTIA MACROSPERMA C. B. CLARK

本文报道从大籽獐牙菜Swertia macrosperma C.B.Clark的全草中分离得到的另外四个化合物Ⅰ～Ⅳ。经光谱及化学方法鉴定,化合物Ⅰ是一种咖啡酸双糖酯类化合物,其结构为反式咖啡酸-1-O-芦丁糖酯(trans caffeic acid-1-O-rutinose ester),系首次从天然界得到的一种新化合物,命名为大籽獐牙菜甙(swertiamacroside);化合物Ⅱ～Ⅳ为已知的(口山)酮衍生物,分别鉴定为芒果甙(mangiferin,Ⅱ),bellidifodin(Ⅲ)及bellidifodin-8-O-β-D-glucopyranoside(Ⅳ)。

From the air-dried whole plant of SwerBia macrosperma C. B.Clark four compounds Ⅰ～Ⅳ were isolated. One of them is a new caffeic acid disaccharide ester. Its structure was elucidated as 1-O-trans-caffeoyl6-O-α-L-rhamnopyranosyl-β-D-glucopyranoside, i. e. trans caffeic acid-1-O-rutinose ester on the basis of chemical and spectroscopic analysis, and named swertiamacroside (Ⅰ). The other three known compounds were identified as mangiferin (Ⅱ), bellidifodin (Ⅲ) and bellidifodin-8-O-β-D-glucopyranoside (Ⅳ).