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手性配体[QN(OH)_2]_2PHAL在烯烃不对称氨羟化反应中的应用

Application of recyclable ligand[QN(OH)_2]_2PHAL to asymmetric aminohydroxylation of olefins
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摘要 以N-氯代氨基甲酸苄酯为氧化供氮试剂,一种可重复使用的手性配体与金属锇形成原位催化剂用于催化5种烯烃的不对称氨羟化(AA)反应,表现了好的对映选择性(85%～99%)和反应活性(49%～72%)。在以对氯苯乙烯为底物的AA反应中,采用了两种不同的回收方法,均能有效地进行配体的回收和再利用,配体的催化活性和对映选择性基本保持不变。 N-chlorocarbamate as oxidant and nitrogen source,A reusable free cinchona alkaloid derivative ligand was applied to asymmetric aminohydroxylation（AA）reaction of five olefins with 85%～99%e.e.and 49%～72%yields.Two different methods for recycling ligand were tried in the AA reaction of p-chlorostyrene,the results showed that this ligand could be easily recovered and reused without any significant loss in its catalytic efficiency.
作者 南鹏娟 陈晶 崔新爱
机构地区 陕西师范大学化学与材料学院
出处 《化学研究与应用》 CAS CSCD 北大核心 2011年第10期1300-1304,共5页 Chemical Research and Application
基金 国家自然科学基金课题(20576068)资助
关键词 可回收的非支载型配体 不对称氨羟化反应 手性Β-氨基醇 reusable free ligand asymmetric aminohydroxylation reaction chiral β-amino alcohol
分类号 O643 [理学—物理化学]
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参考文献13

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二级参考文献18

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化学研究与应用
2011年 第10期

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