摘要
用分散剂法制备了链霉素白蛋白微球,并测定了微球一些物理性质包括微球大小、分布与表面状态。结果表明微球在10～30μm范围内,药物含量为20.3±0.16%。完成了体外释药试验,同时用荧光素异硫氰酸盐与^(125)Ⅰ标记微球进行大鼠体内分布实验。实验证实微球主要集中在肺组织,这对于提高链霉素的疗效降低其毒副作用有重要的意义。
Streptomycin albumin microspheres were prepared by polymeric dispersing agents. Some physical properties including the size, distribution and surface state of the microspheres were determined. The results showed that the diameter of the microspheres ranged from 10 to(30μm and the content was 20.3±0.5%. Drug release from the microspheres was performed by a dynamic dialysis system. Tissue distribution of streptomycin albumin microspheres in rats was studied by both fluorescein isothiocyanate and ^(125)Ⅰ labelled microspheres. The experiments revealed that the major part of the microspheres accumulated in the lung following intravenous injection. The effectiveness and side effects of the streptomycin in the microspheres remain to be determined.
出处
《药学学报》
CAS
CSCD
北大核心
1990年第4期284-288,共5页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
关键词
硫酸链霉素
白蛋白微球
Streptomycin sulfate
Albumin microspheres
