碳糊电极溶出伏安法测定奋乃静等抗精神病药物

STRIPPING VOLTAMMETRIC DETERMINATION OF PERPHENAZINE AND SOME ANTIPSYCHOTIC DRUGS AT CARBON PASTE ELECTRODES

本文报道一种测定吩噻嗪类治疗精神病药物奋乃静、氟奋乃静、氯丙嗪和三氟拉嗪的灵敏电化学分析方法。该类药物在碳糊电极上预富集后,进行溶出伏安测定,溶出电流与浓度在一定范围内具有线性关系。最低检测限可达5ng/ml。用本方法可以不经分离,直接测定药片和人体液中上述药物的含量。作者提出了一种新型挤压式碳糊电极,对上述药物在该电极上的富集机理和测试条件进行了系统研究。认为药物的富集作用是由吸附和萃取引起的,并用计时库仑法定量地估价了这两部分在富集中所起的作用。

A sensitive electrochemical method for the determination of four drugs: perphenazine, fluphenazine chlorpromazine and trifluperazine is reported. These compounds exhibited accumulation at carbon paste electrodes in an open circuit. Differential pulse voltammetric determination gave linear calibration curves in the range of 0.02～1μg/ml. Detection limits found were 5～7ng/ml. The drugs in tablets and body fluids were determined directly, without separation. The preconcentration mechanism and determination conditions in a new kind of carbon paste piston electrodewere investigated. Adsorption and extraction played important roles in accumulation process and the ratio of these two parts was measured by chronocoulometry.