血浆中CRP、Hcy、LDL、HDL含量与动脉粥样硬化的相关性研究

The study on the relationship between plasma levels of CRP,Hcy,LDL,HDL and atherosclerosis

目的通过检测动脉粥样硬化(AS)患者血浆中C反应蛋白(CRP)、同型半胱氨酸(Hcy)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)含量变化,探讨CRP、Hcy、LDL、HDL水平与不同程度冠状动脉粥样硬化的相关性及其在冠心病(CHD)发病机制中的作用。方法使用OLYMPUS 5400全自动生化分析仪和SIEMENS BN-Ⅱ特定蛋白分析仪分别检测211例AS(其中并发CHD患者156例)患者和59例健康人血浆中CRP、Hcy、LDL、HDL的含量,对检测结果进行统计学分析。结果与健康对照组相比,AS组CRP、Hcy、LDL水平均升高,而HDL水平低于健康对照组,差异有统计学意义(P<0.01)。并发CHD组与无CHD组对比,并发CHD组的CRP、Hcy、LDL水平均升高(P<0.01),而HDL低于健康对照组(P<0.01)。不同程度冠状动脉病变组间上述指标水平变化差异有统计学意义(P<0.01)。结论高CRP、Hcy、LDL是AS的危险因素,且与冠状动脉粥样硬化病变程度呈正相关,而HDL水平与冠状动脉粥样硬化病变程度呈负相关,这些指标为CHD患者病情程度的评估提供了重要的依据。并发CHD患者体内CRP、Hcy、LDL水平高于无冠心病患者,而HDL水平明显低于后者,因而这些指标也可用来监测AS患者出现CHD等并发症的危险性。

Objective To study the relations between plasma CRP,Hcy,LDL,HDL levels and different degrees of coronary atherosclerosis（CAS） and its related diseases in the pathogenesis of CHD role.Methods 211 cases of AS（of which 156 cases were complicated with CHD） and 59 cases of normal plasma CRP,Hcy,LDL,HDL levels were detected by OLYMPUS 5400 automatic biochemical analyzer and SIEMENS BN-Ⅱ specific protein analyzer,and the test results were analyzed by statistical methods.Results Compared with the control group,levels of CRP,Hcy,LDL in AS group increased（P〈0.01）,while HDL level was lower than that of the control group（P〈0.01）.Similarly,the levels of CRP,Hcy,LDL in concurrent CHD group increased higher than those of non-CHD group（P〈0.01）,while HDL was lower than that of the control one（P〈0.01）.The levels between the groups of different degrees of coronary artery disease were significant different（P〈0.01）.Conclusion High level of CRP,Hcy,LDL is a risk factor for AS and has a positive correlation with the severity of CHD,while the HDL levels and the severity of CHD are negatively correlated,and these indicators for the assessment of severity in patients with CHD provide an important basis.CRP,Hcy,LDL levels of patients with coronary heart disease are higher than those without coronary heart disease,while HDL levels are significantly lower than the latter,so these indicators are also used to monitor the AS patients with coronary heart disease risk.