淫羊藿和胰岛素在糖尿病骨质疏松治疗中的配伍作用

Compatible Effect of Epimedium and Insulin in the Treatment of Diabetes Osteoporosis

目的观察淫羊藿和胰岛素在糖尿病骨质疏松治疗中的配伍作用。方法将未经胰岛素治疗的糖尿病骨质疏松患者182例分为胰岛素组与淫羊藿配伍组,其中胰岛素组89例,以胰岛素控制血糖为主要治疗,淫羊藿配伍组93例,在胰岛素控制血糖基础上,每天加服淫羊藿中药配方颗粒剂。两组疗程均为6个月。治疗前后测定骨密度等指标,并观察治疗前后疼痛症状的变化和肾虚症状出现频次的变化。结果与胰岛素组比较,淫羊藿配伍组平均疼痛缓解时间显著缩短(P<0.01),骨密度显著提高(P<0.05),肾阳虚症状和肾虚症状总频数改善率差异有统计学意义(P<0.05),肾阴虚症状频数改善率差异无统计学意义。结论加用淫羊藿能提高胰岛素和钙剂治疗糖尿病骨质疏松的疼痛缓解率,配合胰岛素能进一步提高淫羊藿对肾虚症状的治疗作用。

Objective To observe the compatible effect of Epimedium and insulin in the treatment of diabetes osteoporosis. Methods Patients with diabetes and osteoporosis without receiving insulin therapy before were derided into insulin group and Epimedium compatible group. Insulin group with 89 cases was administered insulin as the main treatment to control blood glucose. Epimedium compatible group with 93 cases was given a daily serving of traditional Chinese medicine granules Epimedium on the basis of insulin to control blood glucose. Before and after the treatment for 6 months,the bone mineral density,the changes in pain symptoms and frequency changes of kidney deficiency symptoms were observed. Results Compared with the insulin group,average pain relief time of Epimedlum compatible group was significantly shortened （P〈0.01）, bone density increased significantly （P〈 0.05）, frequencies of kidney yang deficiency symptoms and kidney deficiency symptoms were decreased obviously （P〈0. 05） ,whereas frequencies of kidney yin deficiency symptoms were not statistically significant differences between two groups. Conclusion Epimedium can improve pain relief rate when combined with insulin plus calcium in the treatment of diabetes and osteoporosis. Insulin can further improve the effect of Epimedium in the treatment of kidney deficiency symptoms.