摘要
本文报道了4-甲氧羰基芬太尼4-N-丙酰基结构改变衍生物的合成及其镇痛活性。试验结果表明,该类衍生物均具有典型吗啡样作用的性质。多数化合物具有很强的镇痛活性。其中1379,1385和1387的镇痛活性强于先导物4-甲氧羰基芬太尼。
In the present paper, the synthesis and analgesic activities of some 4-N-propionyl analogs of 4-methoxycarbonyl fentanyl are reported. In mouse hot plate test, most of these compounds showed strong narcotic analgesic activity. The analgesic activitesof compounds 1379, 1385 and 1387 were found to be more potent than that of 4-methoxycarbonyl fentanyl.
出处
《药学学报》
CAS
CSCD
北大核心
1990年第5期336-339,共4页
Acta Pharmaceutica Sinica
关键词
芬态尼
镇痛活性
丙酰基
4-Methoxycarbonyl fentanyl
Narcotic analgesic activity
Fentanyl
