鸦胆子化学成分的研究

STUDIES ON THE CHEMICAL CONSTITUENTS OF BRUCEA JAVANICA (L.) MERR

继从中药鸦胆子Brucea javanica (L.)Merr的果实中分得一系列具抗肿瘤活性的苦木内酯成分后,又进一步分得一新生物碱和一新苦木内酯,通过理化常数和光谱(UR,IR,~1HNMR,^(13)C NMR)分析,推断其结构分别为4-乙氧甲酰基喹诺-2-酮(4-ethoxyca-

An alkaloid and a quassinoid were isolated from the fruit of Brucea javanica (L.) Merr, and were identified as 4-ethoxycarbonyl-2-quinolone (1) and bruceine Ⅰ (2). Compound 1 was found from natural resource for the first time. The structure of the new compound 2 was elucidated on the basis of spectral data and chemical evidence. Three well known compounds vanillic acid (5), quercetin-3-O-β-D -galactoside(4), and luteolin-7-O-β-D-glucoside (5) were also isolated. All of them were first reported to occur in the Brucea genus.