摘要
本文介绍以光学活性苏-1-(对硝基苯基)-1,3-二羟基丙胺-2为拆分剂,与消旋棉酚缩合,用常压柱色谱或溶剂结晶法分离得到两个光学纯的非对映体,然后分别水解得(+)和(-)-棉酚。
Threo (-) or (+)-1-(p-nitophenyl )-1, 3-dihydroxy propylamine -2 was found to be a useful resolving agent for racemic gossypol. The optical and chemical stability of the condensate of enantiomeric gossypols with the titled amine and the great difference in the Rf values on TLC and the solubilities in various solvents between the two diastereoisomeric condensates facilitate the separation.Therefore,the pure isomers can be easily obtained by means of chromatography or crystallization.
出处
《药学学报》
CAS
CSCD
北大核心
1990年第6期430-434,共5页
Acta Pharmaceutica Sinica
关键词
棉酚
消旋反应
Gossypol
(+)or (-)- Gossypol
Threo (-)or (+)- 1- (p-nitrophenyl)-1, 3 - dihydroxy propylamine - 2
