恶性蝾螈瘤的临床病理学诊断

The clinical pathologic diagnosis of the malignant triton tumor

目的复习文献,对恶性蝾螈瘤的临床病理特点、组织学起源及病理诊断和鉴别诊断等进行探讨。方法对肿瘤的标本做常规石蜡切片及HE染色,光镜观察,并对石蜡切片做免疫组化染色。结果患者为男性,54岁,因上腹部饱胀做B超检查发现腹腔内有巨大的肿块,镜下见在肿瘤内含有恶性神经鞘瘤及横纹肌肉瘤两种成份,免疫组化染色见瘤细胞表达S-100、myoglobin及desmin阳性。结论恶性蝾螈瘤的发病部位十分广泛,肿瘤可见于任何年龄的患者,患者以男性多于女性,位于腹腔内的肿瘤常体积巨大,肿瘤常呈广泛地浸润性生长,患者的预后不良。本文尚对恶性蝾螈瘤的诊断标准及鉴别诊断等进行了探讨。

Objective To review the literature and probe the clinical pathological features,histogenesis,pathological diagnosis and differential diagnosis of the malignant triton tumor.Methods The tumor was studied by using of paraffin slice,HE staining,and observed under microscope.The paraffin slices were also stained with immunohischemistrical method.Results The patient was a 54 years old man.Because of the patient＇s feeling of the abdominal distension,a huge mass was found in the abdominal cavity by ultrasound wave examination.Under microscope,there were two components in the tumor,namely,the malignant nerve sheath tumor and rhabdomyosarcoma.By immunochemical stain,the tumor cells expressed the S-100,myoglobin and desmin positive.Conclusions The malignant triton tumor could be found in various locations of the bodies,and the tumors could be seen in any ages of the patients.The male patients were often more than female patients.If a tumor was located in the abdominal cavity,it usually formed a huge mass.The tumor often massively infiltrated the peripheral tissue,and the patients＇ prognoses were bad.In this article,the diagnosis criterion and the differential diagnoses were also discussed.