N,N′-亚烷基双(取代苯酚)氨基乙酸的合成及对放射性核素钍-234的促排效果

SYNTHESIS OF N,N '-ALKYLENE-BIS-(SUBSTITUTEDPHENOL)GLYCINE FOR REMOVAL OF RADIO-ACTINIDES IN RATS

本文报道合成的16个N,N′-亚烷基双(取代苯酚)氨基乙酸除化合物3,4外对放射性钍-234的加速排出均有较好的效果。其中有二个化合物促排效果达到70％以上,根据动物实验结果初步探讨了构效关系。

The synthesis of 16 compounds of N, N'-alkylene-bis (substituted phenol) glycine is reported. They showed good effects on the removal of redinuclide thorium-234 from rats, except compound 3 and compound 4. Two of them can remove more than 70% of injected thorium. The relationship between structure and effects of these compounds was discussed.